Research
The Flamio Lab studies how microbial recognition systems evolve and how genomic regulation shapes immune function across vertebrates.
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Evolution of Microbial Recognition Systems
Evolution of Microbial Recognition Systems
A major focus of the lab is understanding how duplicated immune genes diversify to produce new regulatory and functional outcomes. We use Toll-like receptor (TLR) pathways as model systems to investigate how sequence evolution, transcript isoforms, untranslated regions (UTRs), and noncoding regulatory elements influence immune recognition.
Current projects include:
Evolution and differential regulation of TLR5 paralogs
Comparative analysis of immune receptor regulation across vertebrates
miRNA and RNA-binding protein interactions with immune transcripts
Evolution of microbial recognition molecules
Genomics of Host–Microbe Interactions
The lab also develops genomic resources and investigates how vertebrate hosts interact with their microbial environments. Using genome assembly, transcriptomics, and microbiome approaches, we study immune function in understudied vertebrate species.
Current projects include:
Genome and transcriptome resources for conservation-relevant fishes
Full-length transcript discovery using Iso-Seq
Tissue-specific immune responses associated with microbial exposure
Host-associated microbial communities in aquatic vertebrates
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