The Flamio Lab studies how vertebrate genomes regulate immune responses to microbes. We uncover the molecular mechanisms that control innate immunity and how their disruption contributes to immune-mediated kidney disorders, including lupus nephritis (LN) and IgA nephropathy (IgAN).

We combine computational and experimental approaches using human immune cell systems alongside comparative analyses across vertebrates to reveal conserved principles of pathogen sensing and immune regulation. This expertise also informs conservation studies, allowing us to investigate how habitat and microbial factors influence the health, immunity, and microbiomes of imperiled native fish species, such as the mud sunfish (Acantharchus pomotis) and blackbanded sunfish (Enneacanthus chaetodon).

The lab provides trainees with interdisciplinary research opportunities at the interface of genomics, immunology, computational biology, and microbiology. We prioritize mentorship and creating a collaborative, inclusive environment where all students can contribute, explore their interests, and develop as scientists.